Feebleness of growth and congenital dwarfism : with special reference to dysostosis cleido-cranialis / by Murk Jansen.

  • Jansen, Murk, 1867-1935.
Date:
1921
Catalogue details

Licence: In copyright

Credit: Feebleness of growth and congenital dwarfism : with special reference to dysostosis cleido-cranialis / by Murk Jansen. Source: Wellcome Collection.

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    It is difficult to imagine that this syndrome, showing itself in the father of a Dysostotic subject, as well as in Dysostotic subjects them¬ selves, should be independent of Dysostosis Cleido-cranio-(digitalis). It i> much more plausible to ascribe it to the same cause, viz. enhanced hydrostatic pressure. Ihe absence of signs of direct pressure then enforces the assumption that hydramnion, i. c. relative rather than absolute smallness of the amnion, has been at fault. And, if we do so, Fig. 36.—(Mrs. Non-dysostotic, but showing “ Syndrome of the short extremities.” we seem to get more intimate information about the effect and operation of smallness of the amnion. In view of the fact, indeed, that the basal phalanges are properly developed and the widened ends of the terminal phalanges are also present, we are forced to assume that the increase of hydrostatic pressure has taken place a short time after the basal phalanges changed into cartilage and has been lowered before the ends of the terminal phalanges adopted their cartilaginous consistency. From this it 'would follow that enhanced hydrostatic pressure in these cases has lasted only a very short time,'for hours rather than for days. It should be noted that in all probability this is nothing unusual. The very fact that