On the pathology and treatment of albuminuria / by William H. Dickinson.

  • Dickinson, W. Howship (William Howship), 1832-1913.
Date:
1877
Catalogue details

Licence: Public Domain Mark

Credit: On the pathology and treatment of albuminuria / by William H. Dickinson. Source: Wellcome Collection.

    34/476 (page 10)
    and in the blood¬ vessels. Anatomi¬ cal divi¬ sion. the path of the new growth is compressed or destroyed. This change is declared to the naked eye by contraction and superficial granulation. In the second case, that of diffuse intertubal fibrosis, the change belongs to the terri- tory of the capillaries rather than of the arteries. It is evenly spread everywhere between the tubes, where it is rather to be appreciated by hypernucleation than by tan¬ gible breadth of new growth. It has its chief importance as a complication and consequence of tubal inflammation, and may exist without any inequality of surface. Thirdly.■—There is a peculiar material, recognized by its e amyloid ’ reaction with iodine, which appears, if we may make such a distinction, to be rather a chemical pro¬ duct than a vital growth, which is poured out not only into the kidney but simultaneously into many organs, as the result of a certain state of blood. This substance starts from the blood-vessels and infiltrates the whole organ, giving it the appearance described as wax}^ or lardaceous. This, and the reaction by which it is iden¬ tified, is not found save as the result of a very definite disorder, dependent, so far as we know, only upon antece¬ dent disease. Glassification of Albuminuria. Thus it appears that if we take a rough division of the gland into the three structures which enter into its formation—the secreting tubes with their epithelial lin¬ ing, the fibrous tissue between them, and the blood-vessels with the blood they contain, we have three loci of disease. Either of these structures may be primarily the seat of morbid change; and the alteration may remain for a long time, or even to the end, confined to the portion of the organ in which it has begun. Hence we have disease of the tubes, disease of the fibrous tissue between them, and disease of the blood¬ vessels. This is not a mere scholastic classification. Kidneys